Low dose angiotensin converting enzyme inhibition and glomerular permselectivity in renal transplant recipients

Angiotensin Converting Enzyme in Sarcoidosis

Sirolimus and angiotensin-converting enzyme inhibitors together induce tongue oedema in renal transplant recipients.

Sirolimus (rapamycin; SRL) is a macrocyclin lactone with a novel mechanism of immunosuppression. Via its c-7 methoxy group, SRL cross-links the immunophilin FK binding protein 12 (a peptide-prolyl isomerase that acts as a folding catalyst) to the multifunctional serinethreonine kinase, the mammalian target of rapamycin [1]. By blocking co-stimulation signals, SRL prevents the activation of the ...

PREGNANCY IN RENAL TRANSPLANT RECIPIENTS

 ABSTRACT Background: Correction of the uremic state by a functioning allograft often restores fertility in women of reproductive age. The rate of fertility significantly differs between industrial countries, developing and middle east countries. On the other hand the results of pregnancy in Kidney Transplantation (KTP) patients are significantly better than hemodialysis patients, and pregnancy...

Primary renal renin secretion responding to angiotensin converting enzyme inhibition.

A case of primary renal renin secretion of probable neoplastic origin is reported. Investigation demonstrated renin secretion to be incompletely autonomous with suboptimal suppression to posture and hypervolaemia. Easy control of the hypertension and hypokalaemia was achieved with an angiotensin converting enzyme inhibitor. Such treatment may prove to be a preferable option to surgery.

Nephrectomy, converting enzyme inhibition, and angiotensin peptides.

To determine the contribution of kidney-derived renin and angiotensin converting enzyme to circulating and tissue levels of angiotensin peptides, we measured angiotensin (Ang)-(1-7), Ang II, Ang-(1-9), and Ang I in plasma, kidney, lung, heart, aorta, brown adipose tissue, adrenal, pituitary, and brain of five groups of male Sprague-Dawley rats: control rats, rats given the converting enzyme inh...